BioProfile® pHOx® is a compact analyzer for measurement of acid base and respiratory parameters and is specifically designed to fit the requirements of biotech environments. In addition to an off-line metabolite analyzer (e.g. BioProfile® 100 Plus), it is the ideal choice for at-line analyses next to bioreactors. Automatically performed calibrations, completed in less than 5 minutes, allow for 24/7 system availability. Sample analysis time is 45 seconds. 3 levels of onboard quality controls can run automatically at programmable times. This feature allows operators to easily verify full system functionality prior to running sample analyses. There are comprehensive IQ-OQ procedures and documents available for the BioProfile® pHOx®.
Differences between BioProfile® pHOx® and common blood gas analyzers
Unlike common blood gas analyzers, BioProfile® pHOx® is optimized to meet the specific requirements of cell culture and bacterial fermentation samples:
- The pH measurement range is as wide as from 5 to 8. In addition to 3 levels of quality controls, there are pH linearity standards available, to cover the very low and high ranges.
- All reagent and QC snap-in cartridges are closed, chip-coded and their covers consist of plastic, which allows for easy operation even in GMP and production sites.
- After sample aspiration, the flow path is closed. The waste bag is integrated in the reagent cartridge, and so are all required calibration standards. No external containers are needed.
- Additionally to the measured tests pH, pCO2 and pO2, the system calculates the following listed tests: Total CO2, Bicarbonate, Air Saturation, CO2 Saturation