Bioprofile® FLEX 2 SK

BioProfile® FLEX2

BioProfile® FLEX2 combines Nova’s groundbreaking MicroSensor Card technology with optical measurement and freezing point osmometry for an automated and comprehensive cell culture analyzer that eliminates chemistry sensor maintenance, increases analyzer speed, and reduces sample volume.

The full 16 cell culture test menu includes Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca++, pH, PCO2, PO2, total cell density, viable cell density, viability, cell diameter, osmolality


Maintenance-free Mircosensor Cards

Compared to the previous generation BioProfile® FLEX there is no maintenance for any of the 11 chemistry and gas sensors (Gluc, Lac, Gln, Glu, NH4+, Na+, K+, Ca++, pH, PCO2, PO2). Chemistry and gas biosensors are combined in the credit card sized MicroSensor Card, which uses proven Nova biosensor technology that has been validated in thousands of cell culture processes. MicroSensor Cards have a maintenance-free, onboard minimum use life of 14 days and are replaceable in seconds.

Fast analysis time

Comprehensive test results including cell density/ viability, pH/gases, and key chemistries are available in four minutes. Throughput for individual modules is as fast as 105 seconds.

Onboard automated quality control

Automated onboard quality controls save hours of labor each week compared to manual control testing, using several levels of control ampules. The liquid quality controls of the FLEX2 are provided in closed, chip-coded cartridges, which can be used up to 30 days and run automatically at user-selected intervals.

Automated, 96-well plate analysis

In addition to sampling from syringes and its load-and-go tray, FLEX2 is the only cell culture chemistry analyzer to offer automated sampling from 96-well plates. Plate configurations with mixed test panels may be saved for efficient loading of future plates with the same configuration.

Ideal for GMP Areas

The user-friendly software is fully compliant with 21 CFR Part 11.  The persistence of this conformity is being maintained by the manufacturer through the usage of state-of-the-art technology and by providing continuous updates. This makes the FLEX2 the ideal analyzing system for GMP areas.

BioProfile FLEX2 Systemintegration

BioProfile FLEX2 enables automatic sampling for every size of bioreactor. An integration is possible from 14 mL microscale reactor to the tallest SIP/CIP production units, including data management and automatic feedback control of every measured parameter. Unlike to other integrated analysers can the FLEX2 still be used for manual measurement as well as sample tray analysis, despite being integrated.

The combination of FLEX2 and ambr® 15 microscale bioreactor offers a range of unique advantages:

  • fully automated sampling and data management
  • automatic feeds, pH adjustment and other prozess optimization
  • Walkaway-automation with 24 vessel systems for up to 10 days
  • complete elimination of weekend shifts
  • saves app. 8 working hours for manual sampling per day
  • Up to 8 sampling sequences possible per vessel
  • analyses all key parameters out of only 400 µl sample